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更新于 7月17日

類器官研發(fā)項目負責人——神經(jīng)方向

2.5-5萬·13薪
  • 上海奉賢區(qū)
  • 1-3年
  • 博士
  • 全職
  • 招1人

職位描述

細胞培養(yǎng)技術細胞藥物神經(jīng)
We are seeking a motivated and skilled scientist to lead and support
organ chip research projects focused on modeling neurodevelopment and
evaluating the effects of nutritional components. The ideal candidate will have
a strong background in developmental neuroscience, organoid culture, and
microphysiological systems.
Key Responsibilities:
  • Independently
    design and execute organoid/organ chip-based research projects related to
    brain development, including modeling of neuronal, glial, and blood-brain
    barrier (BBB) compartments.
  • Develop and
    optimize protocols for the differentiation and co-culture of iPSC-derived
    neurons, microglia, astrocytes, and/or BBB components.
  • Establish 3D
    neurodevelopmental models and evaluate the impact of nutritional compounds
    (e.g., DHA, HMOs, prebiotics, micronutrients) on neuronal maturation,
    synaptogenesis, inflammation, and functional connectivity.
  • Implement
    cellular, molecular, and functional assays (e.g., immunostaining, qPCR,
    cytokine profiling, calcium imaging, multi-electrode array recording) to
    assess organoid responses to nutritional interventions.
  • Contribute to
    the development of a functional screening platform for evaluating the
    efficacy of bioactive nutritional components.
  • Coordinate
    project progress, ensure high-quality data collection and analysis, and
    participate in manuscript and report writing in both Chinese and English.
Preferred Qualifications:
  • PhD or
    equivalent in Neuroscience, Developmental Biology, Biomedical Engineering,
    or related fields.
  • Experience with
    human iPSC culture and neural differentiation is essential.
  • Familiarity
    with organ-on-a-chip systems or advanced 3D culture models.
  • Knowledge of
    nutritional neuroscience, gut-brain axis, or neuroinflammation is a strong
    plus.
  • Proven ability
    to manage and execute multidisciplinary research projects.
  • Excellent
    communication skills and scientific writing ability in both English and
    Chinese.
崗位描述:神經(jīng)科學方向科研人員——用于營養(yǎng)神經(jīng)發(fā)育研究的類器官/器官芯片模型
我們正在招聘一位積極進取、具備扎實科研能力的科研人員,主導和參與器官芯片相關研究項目,重點聚焦于神經(jīng)發(fā)育模型的構建及營養(yǎng)成分對其影響的機制研究。理想候選人應具備神經(jīng)發(fā)育、生物工程或類器官培養(yǎng)等相關背景。
崗位職責:
  • 獨立設計并執(zhí)行基于類器官/器官芯片的神經(jīng)發(fā)育相關研究項目,包括神經(jīng)元、膠質(zhì)細胞和血腦屏障等模塊的建模;
  • 建立并優(yōu)化人源iPSC分化為神經(jīng)元、小膠質(zhì)細胞、星形膠質(zhì)細胞及血腦屏障等細胞類型的培養(yǎng)和共培養(yǎng)體系;
  • 構建三維神經(jīng)發(fā)育模型,系統(tǒng)評估營養(yǎng)成分(如DHA、人乳低聚糖、益生元、微量元素等)對神經(jīng)發(fā)育過程中的成熟、突觸形成、炎癥反應及功能連接的影響;
  • 應用細胞與分子生物學方法(如免疫染色、qPCR、細胞因子分析、鈣成像、多電極陣列記錄等)評估類器官對營養(yǎng)干預的反應;
  • 參與營養(yǎng)功能成分的篩選平臺開發(fā),推動其在功能驗證中的應用;
  • 協(xié)調(diào)項目進展,確保高質(zhì)量數(shù)據(jù)收集與分析,撰寫項目報告與中英文科研論文。
任職要求:
  • 擁有神經(jīng)科學、發(fā)育生物學、生物醫(yī)學工程或相關專業(yè)的博士學位;
  • 具有人源iPSC培養(yǎng)及神經(jīng)分化經(jīng)驗;
  • 熟悉類器官/器官芯片系統(tǒng)或先進三維培養(yǎng)技術;
  • 具有營養(yǎng)神經(jīng)科學、腸-腦軸或神經(jīng)炎癥研究經(jīng)驗者優(yōu)先;
  • 具備良好的項目管理和跨學科協(xié)作能力;
  • 具備優(yōu)秀的中英文溝通能力和科研寫作能力。

工作地點

上海奉賢區(qū)臨港南橋科技綠洲

職位發(fā)布者

邢彩霞/人事經(jīng)理

三日內(nèi)活躍
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