We are seeking a motivated and skilled scientist to lead and support
organ chip research projects focused on modeling neurodevelopment and
evaluating the effects of nutritional components. The ideal candidate will have
a strong background in developmental neuroscience, organoid culture, and
microphysiological systems.
Key Responsibilities:
- Independently
design and execute organoid/organ chip-based research projects related to
brain development, including modeling of neuronal, glial, and blood-brain
barrier (BBB) compartments. - Develop and
optimize protocols for the differentiation and co-culture of iPSC-derived
neurons, microglia, astrocytes, and/or BBB components. - Establish 3D
neurodevelopmental models and evaluate the impact of nutritional compounds
(e.g., DHA, HMOs, prebiotics, micronutrients) on neuronal maturation,
synaptogenesis, inflammation, and functional connectivity. - Implement
cellular, molecular, and functional assays (e.g., immunostaining, qPCR,
cytokine profiling, calcium imaging, multi-electrode array recording) to
assess organoid responses to nutritional interventions. - Contribute to
the development of a functional screening platform for evaluating the
efficacy of bioactive nutritional components. - Coordinate
project progress, ensure high-quality data collection and analysis, and
participate in manuscript and report writing in both Chinese and English.
Preferred Qualifications:
- PhD or
equivalent in Neuroscience, Developmental Biology, Biomedical Engineering,
or related fields. - Experience with
human iPSC culture and neural differentiation is essential. - Familiarity
with organ-on-a-chip systems or advanced 3D culture models. - Knowledge of
nutritional neuroscience, gut-brain axis, or neuroinflammation is a strong
plus. - Proven ability
to manage and execute multidisciplinary research projects. - Excellent
communication skills and scientific writing ability in both English and
Chinese.
崗位描述:神經(jīng)科學方向科研人員——用于營養(yǎng)神經(jīng)發(fā)育研究的類器官/器官芯片模型
我們正在招聘一位積極進取、具備扎實科研能力的科研人員,主導和參與器官芯片相關研究項目,重點聚焦于神經(jīng)發(fā)育模型的構建及營養(yǎng)成分對其影響的機制研究。理想候選人應具備神經(jīng)發(fā)育、生物工程或類器官培養(yǎng)等相關背景。
崗位職責:
- 獨立設計并執(zhí)行基于類器官/器官芯片的神經(jīng)發(fā)育相關研究項目,包括神經(jīng)元、膠質(zhì)細胞和血腦屏障等模塊的建模;
- 建立并優(yōu)化人源iPSC分化為神經(jīng)元、小膠質(zhì)細胞、星形膠質(zhì)細胞及血腦屏障等細胞類型的培養(yǎng)和共培養(yǎng)體系;
- 構建三維神經(jīng)發(fā)育模型,系統(tǒng)評估營養(yǎng)成分(如DHA、人乳低聚糖、益生元、微量元素等)對神經(jīng)發(fā)育過程中的成熟、突觸形成、炎癥反應及功能連接的影響;
- 應用細胞與分子生物學方法(如免疫染色、qPCR、細胞因子分析、鈣成像、多電極陣列記錄等)評估類器官對營養(yǎng)干預的反應;
- 參與營養(yǎng)功能成分的篩選平臺開發(fā),推動其在功能驗證中的應用;
- 協(xié)調(diào)項目進展,確保高質(zhì)量數(shù)據(jù)收集與分析,撰寫項目報告與中英文科研論文。
任職要求:
- 擁有神經(jīng)科學、發(fā)育生物學、生物醫(yī)學工程或相關專業(yè)的博士學位;
- 具有人源iPSC培養(yǎng)及神經(jīng)分化經(jīng)驗;
- 熟悉類器官/器官芯片系統(tǒng)或先進三維培養(yǎng)技術;
- 具有營養(yǎng)神經(jīng)科學、腸-腦軸或神經(jīng)炎癥研究經(jīng)驗者優(yōu)先;
- 具備良好的項目管理和跨學科協(xié)作能力;
- 具備優(yōu)秀的中英文溝通能力和科研寫作能力。