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Associate Director / Director Of Peptide(J10057)

3-5萬
  • 北京昌平區(qū)
  • 經(jīng)驗不限
  • 博士
  • 全職
  • 招1人

職位描述

藥物合成
崗位職責(zé):
1.Early-Stage Peptide Synthesis & Scale-Up:
oLead synthesis/purification of complex peptides (>50 aa, cyclic, multi-disulfide, non-natural amino acids) for hit-to-lead optimization.
oDevelop scalable processes (SPPS/LPPS) from mg to 100g scale with focus on speed, purity, and cost-efficiency.
oTroubleshoot challenging sequences (e.g., hydrophobic peptides, aggregation-prone motifs).
2.Technology & Platform Innovation:
oSpearhead R&D initiatives for novel peptide modalities:
?Antibody-peptide conjugates (APC)
?Peptide nucleic acids (PNA)
?Stapled peptides, cell-penetrating peptides (CPP), or other advanced scaffolds.
oEvaluate and implement cutting-edge tools (e.g., flow chemistry, AI-assisted design, automated purification).
3.Client Project Leadership:
oServe as primary scientific contact for clients: design synthetic routes, advise on feasibility, and deliver data-rich reports.
oManage timelines for fast-turnaround discovery projects (e.g., 100s of analogs for SAR).
oMeet or exceed client’s expectation
4.Operational Excellence:
oOptimize lab workflows for high-throughput synthesis and purification (HPLC/UPLC).
oOversee analytical characterization (LC-MS, HPLC) and ensure data integrity.
5.Team Development & Strategy:
oMentor chemists in advanced peptide synthesis techniques.
oCollaborate with leader and BDs together to develop business opportunities.
oIdentify new service opportunities and deliver more materials for business development (e.g., PNA synthesis, bioconjugation).
任職要求:
?PhD in Organic/Peptide Chemistry + 4+ years (or MS + 7+ years) in peptide synthesis (CRO/biotech preferred).
?Expertise in synthesizing complex peptides (e.g., long sequences, multi-cyclic peptide synthesis).
?Proven peptide scale-up experience.
?Passion for innovation (e.g., publications/patents in novel peptide chemistries).
?With rich organic synthesis experience.
?Fluent English (written and spoken) for technical client communications, report drafting, and scientific literature synthesis.

工作地點

北京昌平區(qū)保諾科技

職位發(fā)布者

俞屹鳳/招聘主管

昨日活躍
立即溝通
公司Logo保諾生物科技(江蘇)有限公司
保諾科技是一家國際化生命科學(xué)研發(fā)公司，專業(yè)為生物制藥客戶提供從靶標(biāo)識別到III期的一體化藥物研發(fā)服務(wù)。保諾科技在大小分子發(fā)現(xiàn)和專利技術(shù)平臺方面擁有深厚而豐富的治療專業(yè)知識，在大幅度加快客戶先導(dǎo)化合物發(fā)現(xiàn)項目的進度方面擁有得天獨厚的條件。保諾特點：總部位于美國的CRO，并堅持國際標(biāo)準（包括知識產(chǎn)權(quán)保護、安全和人事標(biāo)準）擁有成功為客戶執(zhí)行一體化生物研發(fā)項目良好業(yè)績一個機制靈活的合作伙伴，且有一支位于美國的項目管理團隊協(xié)助實時溝通開發(fā)、快樂、充滿激情的美國生物科技公司文化保諾榮譽：國家高新技術(shù)企業(yè)國際AAALAC認證北京生物醫(yī)藥產(chǎn)業(yè)跨越發(fā)展工程（G20工程）企業(yè)北京科技研究開發(fā)機構(gòu)國際科技合作基地中關(guān)村高新技術(shù)企業(yè)保諾無錫于2020年8月投入使用，擁有hTME-3DX, FBDD, DEL,抗體研發(fā)，細胞治療等國際先進的技術(shù)平臺。占地面積： 30,000平方米專業(yè)服務(wù)：藥物化學(xué)，藥理學(xué)，發(fā)現(xiàn)生物學(xué)，藥代動力學(xué)，藥效學(xué)，大分子藥物研發(fā)，制劑學(xué)，化學(xué)工藝開發(fā)。
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